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We identified dissolved oxygen and contaminating metal ions as the primary factors responsible for this loss of activity

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Liver carboxyesterase Zwitter ionic Polar Easily excreted General notes regarding phase-I metabolism Esters that are sterically hindered are hydrolyzed more slowly and may be appeared unchanged in urine: General notes regarding phase-I metabolism Amides are more stable to hydrolysis than esters.large fraction of amide containing drugs are normally excreted unchanged

10.1016/j.foodchem.2024.139661 [DOI] [PubMed] [Google Scholar] Huang P, Wang Z, Cheng Y, Gao W, Cui C

[DOI] [PMC free article] [PubMed] [Google Scholar] 194.Nugroho P., Wiryawan K.G., Astuti D.A., Manalu W