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A loading dose uses the exact same agent given at higher doses for the purpose of achieving relevant concentrations faster than simply giving a maintenance dose at the beginning of treatment

Tocilizumab as monotherapy or combination therapy for treating active rheumatoid arthritis: a meta-analysis of efficacy and safety reported in randomized controlled trials

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Transcriptional Activation of Indoleamine Dioxygenase by Interleukin 1 and Tumor Necrosis Factor in Interferon-Treated Epithelial Cells

[PubMed: 9734366] 34

Losartan medication could enhance the outcome of TBI mice