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From 20 to 100 animals (typically 50) per strain per trial were used for the assays, with average percent of animals surviving for 15 h drawn from five independent, biological trials

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In some cases, there is a direct pathological link between the antibody and specific movement disorders like antiphospholipid antibodies and chorea but that is not the case in most autoimmune dystonia

Dystonia offers a window into the mechanisms whereby subtle changes in neuronal function, particularly in sensorimotor circuits that are associated with motor learning and memory, can corrupt normal coordination and lead to a disabling motor disorder

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