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doi: 10.3748/wjg.v30.i15.2143 166 AlanaziAZAlqinyahMAlhamedASMohammedHRaishMAljerianKet al

doi: 10.1016/S0924-2244(98)00027-2

In the two crystal structures of normal human G6P, Pro172 is seen exclusively in the cis conformation, while in the crystal structure of one disease causing mutant (variant Canton R459L), Pro172 is seen almost exclusively in the trans conformation

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However, studies that have investigated GABA B binding in the frontal cortex 61,62 and in the temporal cortex and hippocampus 62 found no evidence of altered GABA B -receptor binding, with the exception of an increased affinity in the temporal cortex of drug-free suicide victims