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So when this metabolite and its mitochondrial transporter showed up in cancer screenings, Birsoy knew where to take his experiments next

Journal of Clinical Investigations

Finally, epigenetic regulation via histone modification, such as acetylation of methylation at the NLRP3 promoter and DNA methylation, silences NLRP3 expression and further refines its transcriptional control, highlighting the intricate regulation of this critical inflammasome component [52]

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Our tinnitus model, however, does not involve hearing loss, which could account for the differences in TNF- expression