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Probiotics, defined as live microorganisms that confer health benefits when administered in appropriate amounts, exert systemic regulatory effects highly relevant to the management of hypothyroidism
Mayatepek E, Hoffmann GF, Carlsson B, Larsson A, Becker K: Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency

The materials reviewed for this article didn't specify how many patches to wear at once or exactly where on the body to apply it beyond general transdermal-patch practice

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