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Skeletal muscle normally expresses the neuronal (nNOS) and the endothelial (eNOS) isoforms of NO synthase (NOS)

Chen, L., Liu, P., Feng, X

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G., Arul, V., Kumar, M

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As a consequence, human cells with additional chromosomes suffer from proteotoxic stress, as documented by increased sensitivity to chaperone inhibitors, accumulation of ubiquitin- and p62-positive cytosolic bodies and increased lysosomal stress 8,9,14,15,16,18
