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In a rat model of SCI, sodium selenite administration significantly reduces iron, MDA, and 4-HNE levels while enhancing the FSP1/GPX4 pathway, ultimately improving motor function [87]

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Moreover, this study found that the catalytic triad of GPx4 is located on a flat surface surrounded by basic amino acid patches, K48/K135/R152/T139, and this particular conformation supports its broad-spectrum substrate specificity, and several studies have demonstrated that the molecular weight of GPx4 proteins is 19-22 kDa