drug causes cysteine starvation glutathione depletion mrc-5 Pyroglutamic acidosis Regulators of the transsulfuration pathway
Description
We found that DEM 1 mM induced death in 4 day old adult worms (at the end of their reproductive phase) in a dose- and time-dependent manner, with 50% lethality occurring after 24 hr exposure to 10 mM DEM (Figure 1A) associated with 50% depletion of glutathione (Figure 1B)

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Consequently, the two chimeric peptides achieved more efficacy in protecting the cell against oxidative damage than GHK

Also, due to the lack of benzyl alcohol, sterile water for injections can only be used once, since it can easily become contaminated
