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Unlicensed synthetic nootropics may be considered controlled substances under the Psychoactive Substances Act

In addition, the composition may contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents, and the like

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The phrase without the involvement of any other agency (although, rarely, complement is included) indicates that neutralization is typically measured in vitro by incubating antibodies, virus particles and target cells together and demonstrating reduced infection