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This bidirectional NO interaction gives this compound an adaptability in biological environments that single-pathway peptides lack, and may contribute to its consistency of effect across diverse tissue types and experimental conditions

The contribution of CAV-1 to angiogenesis is controversial

168 This strategy exploits the acidic pH of the tumor milieu to enable selective insertion and delivery, thereby enhancing targeting precision

However, this added freedom reduces stability and makes ring dips more challenging initially

doi: 10.1371/journal.pone.0027961