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Clinical background variables Clinical data were collected from an electronic patient record, including information (i) before delivery (maternal glucocorticoid administration, chorioamnionitis, pregnancy-induced hypertension, multiple births, intravenous tocolysis, maternal hospital stay until delivery, and delivery mode), (ii) after birth (gestational age, sex, Apgar scores, intrauterine growth restriction, and requirement for invasive/non-invasive mechanical ventilation), and (iii) at the time of the study (postnatal age, feeding mode, clinical record of postnatal glucocorticoid administration, requirement for non-invasive mechanical ventilation using a nasal continuous positive airway pressure device, and invasive blood sampling in the morning of the study)

Transcriptomics analysis of transgenic embryonic mouse cells showed that Pax1 and Pax9 positively regulate many genes associated with cartilage formation and activate expression of chondrogenic genes during early IVD differentiation (Sivakamasundari et al., 2017)

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