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In addition to impacting the mitochondria directly, various metabolites produced by pathogenic bacteria have been shown to have significant effects

Several molecular mechanisms of action including induction of oxidative stress as characterized by reactive oxygen species production and lipid peroxidation, induction of p53 signaling and cell cycle arrest, down-regulation of proto-oncogenes and anti-apoptotic proteins, and activation of both intrinsic and extrinsic pathways of apoptosis

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[PubMed] [Google Scholar] 41.Antholine W.E., Petering D.H., Pickart L

Remarkably, the bioassay enabled the sensitive detection of S-protein at levels as low as 0.01 nM (0.26 ng mL 1 ) in SARS-CoV-2 variants

The time taken to complete IRB review also varies substantially