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Exposure to these metals increases oxidative stressa harmful cellular condition caused by excess reactive oxygen specieswhich activates defense mechanisms
Circ Res 93: 96105, 2003

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Serum iron levels are reduced by negatively regulating the expression of duodenal iron transporters (DMT1 and FPN1) and TfR1 ( 2+ and Fe 3+ )
In certain stages of life such as the elderly and those who are vegetarian, vegan, individuals with limited meat and dairy intake have been found to have low levels of vitamin B12

10.1016/j.tiv.2009.06.014
