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doi:10.6133/apjcn.201912_28(4).0013 Lopez, Michael J., et al

reported that the protein kinase r-like endoplasmic reticulum kinase (PERK), activating transcription factor 4 (ATF4), and the C/EBP homologous protein (CHOP) expressions were increased and Fe 2+ concentrations were elevated in rats with ischemia/reperfusion lung injury, suggesting that this injury may trigger iron-dependent cell death by activating the endoplasmic reticulum

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The apheresis product typically contains lymphocytes, including T cells, monocytes, granulocytes, B cells, other nucleated white blood cells, red blood cells, and platelets

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Additionally, the downstream metabolism of fructose contributes to ROS generation through its consumption of ATP for its conversion to fructose-1-phosphate and fructose-1,6-bisphosphate