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Mengstie MA, Wondimu BZ (2021) Mechanism and applications of CRISPR/Cas-9-mediated genome editing

Mol Cell Biol 34:900913 Tsakiri EN, Gumeni S, Iliaki KK, Benaki D, Vougas K, Sykiotis GP, Gorgoulis VG, Mikros E, Scorrano L, Trougakos IP (2019) Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

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In general, natural compounds have been shown to be able to reverse hypermethylation and the reactivation of tumor suppressor genes (23)

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