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Ment Health Clin 6(4):165170

In addition to RIDD, IRE1 also induces non-conventional splicing and activation of XBP1, a major transcription factor regulating ER homeostasis 10,66,67,68,69
2011;6(8): e23710

Morkbak AL, Hvas AM, Milman N, Nexo E
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They are sometimes paired with hormone replacement therapy protocols and are not FDA-approved, so dosing is individualized and monitored
