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Pathophysiological links between rheumatoid arthritis and the EpsteinBarr virus: an update

However, long-term activation of an opioid receptor with either chronic use or abuse of opioids leads to highly undesirable and clinically significant side effects

182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)

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10.1016/j.jpsychires.2006.07.013 J Psychiatr Res

Discussion The major findings of this study are as follows: (1) BPC 157 induces an ex vivo nitric oxide-mediated relaxation of large vessel in a concentration-dependent manner