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Thiol groups are reducing agents, glutathione reduces disulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor

10.1093/brain/awl023 45

The GSH donorsNAC and UDCA increase the beneficial effects of GSH in different cell culture and animal models and the opposite effects were observed with the agents causing GSH depletionBSO and DEM

The intervention showed significant effects, with the EPA group experiencing fewer monthly migraine days, reduced usage of headache medication, and improvements in headache severity (VAS score), disability (MIDAS score), anxiety and depression (HADS score), and quality of life (MSQ score)

6.) Protection against "free"radicals