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THE GH, IGF-1, AND INSULIN INTERPLAY IN TYPE 2 DIABETES MELLITUS AND OBESITY Patients with chronic liver disease are prone to developing sarcopenia, which is defined as loss of skeletal muscle mass, strength, and function, and is associated with increased morbidity and mortality [23]

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doi: 10.3748/wjg.14.5990 [DOI] [PMC free article] [PubMed] [Google Scholar] 248

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Hypoxia initiates HIF2-mediated expression of the hypoxia-inducible lipid droplet-associated protein (HILPDA), resulting in polyunsaturated lipid enrichment [179]