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Using DIO models, typically established with a HFD based on lard, we and others have reported that obesity promotes tumour growth by disrupting NK and CD8 T cell bioenergetics, which precludes an effective anti-tumour immune response 6,7,8

doi:10.1080/03007995.2017.1292230 Tiequn B, Guanqun C, Shuo Z

Especficamente, el metabolismo bacteriano intestinal de la fosfatidilcolina, la principal fuente diettica de colina, ha demostrado producir un metabolito proaterognico, el TMAO, a travs de la formacin inicial de trimetilamina (TMA) en primer lugar, y posteriormente la conversin a TMAO mediada por la enzima heptica flavina monooxigenasa3-5

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