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211 Taking these findings together, AMPK promotes TJ assembly and preserves TJ integrity in response to cellular stress via the phosphorylation of claudin and TJ scaffolds

In this study we evaluated the applicability of the immortalized human cell line hCMEC/D3 for ABC transporter studies, focusing on the most expressed ABC transporters at the human BBB: P-glycoprotein (PGP, ABCB1), multidrug resistance protein 4 (MRP4, ABCC4) and breast cancer resistance protein (BCRP, ABCG2)

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This dual action, lowering destructive inflammation while boosting antioxidant defense, protects tissues from oxidative damage during aging and after injury (PMC3359723)