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reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation

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Neurosci Res 55: 7886

Funding: This study was supported by Grants-in-Aid for Young Scientists (A) (23689022) and Scientific Research on Innovative Areas (22133008) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and Grants-in-Aid from Takeda Science Foundation, SENSHIN Medical Research Foundation and Kowa Life Science Foundation