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The nephropathy developed after 3 weeks of STZ administration

Specifically, the catalytic activities of pyruvate dehydrogenase and -ketoglutarate dehydrogenase are critically dependent on the production of lipoic acid, a straight-chain fatty-acid containing two sulfhydryl groups

Shotgun proteomic analysis revealed that TRIM3 was upregulated in postmortem dorsolateral prefrontal cortex samples obtained from schizophrenia patients compared to its level in healthy individuals [106]

The relative importance of the glutathione system compared to the more important thioredoxin system may be further amplified under acute oxidative challenge as thioredoxins or thioredoxin reductases may readily become limiting and/or oxidised and thus inactive [62], which would strongly limit the capacity of the thioredoxin pathway to act as a conduit of anti-oxidative electron flux

Recent data suggest a transcellular passage, dependent on binding to secretory immunoglobulin A (sIgA) and the transferrin receptor CD71 (88)