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Renal Effects In the kidney, prostaglandins, produced by both COX-1 and COX-2, are important regulators of sodium and water reabsorption through PGE2 and of renal function and hemodynamics via PGI2 in response to vasoconstrictive factors (e.g., endothelin-1, a factor that increases peripheral vascular resistance) and through effects on the renin-angiotensin system

These actions have been reviewed herein, but of special mention during exercise is the recruitment of hippocampal neuroprogenitor cells and improved neuroglia function [289, 290]

Common side effects are usually mild and temporary

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10.1007/s13346-018-00613-y 6 BolamanZ.KadikoyluG.YukselenV.YavasogluI.BarutcaS.SenturkT

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