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The Medical Subject Heading (MeSH) and keywords used were: D-dimer, thrombosis, venous thromboembolism, pulmonary embolism, deep vein thrombosis, cancer, management, treatment, inflammation, disseminated intravascular coagulation, trauma, surgery, infection, sepsis, pregnancy, joint arthroplasty, cardiovascular disease, acute aortic dissection, and coronary artery disease