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Research shows that tVNS improves gut motility and reduces visceral hypersensitivity

Introduction Autoimmune diseases are complex diseases characterized by the loss of immunological tolerance to self-antigens and sustained aberrant immunological response against healthy cells and tissues, leading ultimately to the overproduction of autoreactive immune cells and/or autoantibodies ( CD8+ T cells, also called cytotoxic T lymphocytes (CTL), are one subtype of T cell ( Epigenetics refers to stable and heritable changes in gene expression without involving changes in DNA sequence, which are thought to be connection between environment factors and genetics ( In summary, this review aims to highlight the epigenetic role of CD8+ T cells in the pathogenesis of autoimmune diseases

MacDowall P, Kalra PA, O'Donoghue DJ, Waldek S, Mamtora H, Brown K

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TNFR signaling regulates the transcription of COX2 and PGIS in the spinal cord Two types of TNF receptors, TNF receptor (TNFR) 1 (CD120a