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However, older adults, those on certain medications or with gastrointestinal issues, and people who follow a plant-based diet may be more at risk of deficiency

For de novo NADPH synthesis pathway, correlation studies have revealed that thionicotinamide adenine dinucleotide (NADS) and thionicotinamide adenine dinucleotide phosphate (NADPS), converted from the pro-drug thionicotinamide (TN), act as inhibitors of NADKs through targeting the NAD-binding site of NADKs and decreasing the levels of NADPH

As phase II enzymes, GSTs detoxify chemical compounds through catalyzing nucleophilic attack by the thiol group in reduced glutathione (GSH) on a wide range of electrophilic substrates 37 , 40 , 41

Therefore, a low p62 protein content indicates smooth autophagy downstream

Mahmoudi et al., Advances in Alzheimers diagnosis and therapy: the implications of nanotechnology

doi: 10.2217/fon.12.45