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This hybrid approach is common in protocols studying hepatic lipid mobilization where the initial 710 days benefit from high peak plasma levels, but sustained long-term exposure matters more than acute spikes thereafter

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doi: 10.1152/jn.00850.2002, 89 TangS.MachaalaniR.WatersK

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they do not create a thermodynamic deficit on their own

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Funding This work was supported by the Fogarty International Center of the National Institutes of Health grants D43 TW009744 and D43 TW009337 (SKM), K01HL130497, R03HL155041, and R01HL144941 (AK)

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