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This hybrid approach is common in protocols studying hepatic lipid mobilization where the initial 710 days benefit from high peak plasma levels, but sustained long-term exposure matters more than acute spikes thereafter
doi: 10.1152/jn.00850.2002, 89 TangS.MachaalaniR.WatersK

they do not create a thermodynamic deficit on their own

Funding This work was supported by the Fogarty International Center of the National Institutes of Health grants D43 TW009744 and D43 TW009337 (SKM), K01HL130497, R03HL155041, and R01HL144941 (AK)
