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Metformin may decrease intrinsic factor secretion from parietal cells, interfere with the calcium-dependent binding of the resulting intrinsic factor and B12 complex to receptors on the ileal lining, and change small intestinal motility, resulting in decreased B12 absorption

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A 2.5 mg dose is 2,500 mcg, which at this concentration is 0.75 mL 75 units on a U-100 syringe

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Thus, researchers propose that growth hormone secretagogues like Ipamorelin might elevate fat levels through mechanisms that do not involve growth hormone directly, possibly by enhancing food intake