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Vet Rec 1995;136:568

Abstract Post-exertional malaise (PEM) is a common core symptom in various chronic debilitating conditions, such as Post COVID-19 Condition (PCC, also known as Long COVID) and Chronic Fatigue Syndrome (CFS)

142 Eighteen families with HK deficiency have been described to date, and gene changes have been characterized in only four patients.32,33,56,90,186 Three amino acid substitutions in HK are known to date to affect enzyme stability (p.Leu529Ser) 32,33 or the enzymes active site (p.Thr680Ser)

Moreover, TNF- contributes to endothelial dysfunction by activating the NF-B and mitogen-activated protein kinase (MAPK) signaling pathways, which in turn promote the transcription of additional pro-inflammatory cytokines and apoptosis-related genes

This statistic follows an F distribution with (3, n 2 4) degrees of freedom under the null hypothesis that the two models are equivalent

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