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Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response

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In total, 14 genomic regions have been identified as related to the disease, such as genes involved in IFN production, NKG2Dmediated cytotoxicity (ULBP3/6, MICA, and IL2), T cell activation and proliferation (CTLA4, IL2, IL21, IL2RA, SOCS1, IKZF4/Eos, GARP/LRRC32, SH2B3(LNK)/ATXN2, IL23A, PTPN22, CD28, ICOS, and IL13), HLAs (HLADRB1, C6orf10, BTNL2, HLADRA, HLADQA1, HLADQA2, and HLADQB2), as well as hair folliclerelated genes (STX17, PRDX5, ACOXL/BCL2L11, ERBB3, and CCHCR1) [149, 150, 151, 152, 153]

About this article Cite this article Hao, X., Zhao, B., Towers, M

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Collectively, our findings established increased levels of cell death as a possible pathomechanism of DADA2 and showed that the absence of ADA2 leads to an impairment of the pentose phosphate pathway which may account for the cellular vulnerability of ADA2-deficient cells