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Following administration of phenobarbital via drinking water to F344 rats for three weeks, increased liver weight was found to be a result of hepatocellular hypertrophy, hyperplasia, and enlargement of the hepatic blood space (Massey and Butler 1979)

Ahmed MM, Ibrahim ZS, Alkafafy M, El-Shazly SA

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While a subset of patients with NASH progresses to advanced fibrosis, hepatocyte ballooning, and chronic inflammation, fibrosis stage remains the most reliable predictor of clinical outcomes [102]