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In contrast, oral supplements must pass through the digestive tract, where factors such as stomach acid, enzyme activity, and gut health can affect the absorption rate
PMID: 226 LundellA-CBjrnssonVLjungACederMJohansenSLindhagenGet al
The anti-folate aminopterin was the first anti-folate shown to significantly reduce tumor burden in humans [164]
BMC Pediatr 22 , 590 (2022)
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