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Description
Eprenetapopt is converted to the Michael acceptor methylene quinuclidinone (MQ), which inhibits the antioxidant metabolite GSH (glutathione) by reacting with its thiol groups 14
Clinical studies support this: exposure to diesel exhaust particles (DEPs) reduces peroxisomal ACOX1 expression in bronchial epithelial cells from asthma patients (105), exacerbating PUFA accumulation and ferroptosis
Yamane Y
A high Notch pathway activation predicts response to -secretase inhibitors in proneural subtype of glioma tumor-initiating cells
R.StamerS
& Motohashi, H
