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We focus on small-batch synthesis for a reason

The brain pathology of this disease is similar to that seen in oxidative damage resulting from sulfhydryl depletion due to chronic mercury poisoning (Minamata disease) and is also compatible with decreased cerebral glutathione levels (09)

Biochem Biophys Res Commun 438:721727 Li F, Rajendran P, Sethi G (2010) Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

doi: 10.1073/pnas.2134510100 [DOI] [PMC free article] [PubMed] [Google Scholar]

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Formation of the NFT radical anion is required for Nrf2 activation As activation of Nrf2 requires the oxidation of critical sulfhydryl groups in its interaction partner, Keap1, we investigated the mechanism of this activation by NFT