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The downstream effects of NNMT inhibition by 5-amino-1MQ create a cascade of beneficial metabolic changes at the cellular level

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Interestingly, MOTS-cs effects are not limited to metabolism within mitochondria

The dysfunction of lipid peroxide clearance, the presence of redox-active iron as well as oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are three essential features of ferroptosis