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HuR regulates both GLS splicing and KGA and GAC mRNA stability Since HuR binds to GLS intron 14 and controls its isoform levels, we speculated that HuR controls GLS splicing

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Our previous studies identified a key role for S225 phosphorylation the S225A phosphoablatant mutant had a dramatic phenotype: a loss of p58, a 10-fold reduction in JFH-1 genome replication, a loss of interactions between NS5A and a range of host proteins, and a perinuclear-restricted localisation 23,31