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Andreeff M , Weidner DA, Wang RY, Zhao S, Kuenle I, Kantarjian H, Brenner MK, Goodell MA

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Loss of primary pyruvate dehydrogenase complex enzymatic function may occur from loss of mRNA expression, subunit instability, or loss or reduction of functional activity of various primary pyruvate dehydrogenase complex-associated gene products (Table 2), which could, in part, be due to partial or complete deletion of the specific gene

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