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Whereas Apo CIII coexisting with Apo E on HDL inhibits Apo E binding to receptors and abrogates the benefits of Apo E on HDL clearance

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47 Cerebrovascular atherosclerosis affecting the intracranial, vertebral, and carotid artery systems in the neck and skull can give rise to clots that cause sudden obstructive events such as strokes and transient ischemic attacks (TIAs)