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BME-established organoids from different regions of the gastrointestinal tract also rely on integrin 1 We then tested whether the observed integrin 1-regulated proliferation of intestinal organoids in BME also held for organoids derived from other regions of the human gastrointestinal tract: duodenum ( N = 2), J2 jejunum ( N = 2) and N39 ileum ( N = 2), stomach organoids 31 ( N = 1) and ductal-type organoids from the pancreas 32 ( N = 2) and liver 33 ( N = 2)

In contrast, copper-bound CCS initially transfers copper to XIAP and then CCS is ubiquitinated and targeted for proteasomal degradation

10.1007/s00467-018-4005-4 47 DavidV.MartinA.IsakovaT.SpauldingC.QiL.RamirezV.et al (2016)