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Nature 276, 515517

This comprehensive in vitro study used human liver microsomes and expressed human CYPs to characterize the oxidation of tamoxifen, showing that the conversion of tamoxifen to its secondary metabolite endoxifen occurs through two primary metabolites and is predominantly mediated by CYP2D6, CYP3A4 and CYP3A5
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These data studies suggest that D1-like receptors can also drive phagocytosis, and many of these data suggest the involvement of the cAMP signaling pathway, as D2 activation inhibits cAMP production