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They interact with G-protein-coupled receptors, ion channels, or internal cellular machinery to exert diverse effects, including hormonal stimulation, angiogenesis, mitochondrial regulation, or immune modulation

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DOK3 is a negative regulator of JNK signaling in B cells 42

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doi: 10.1016/j.neuron.2009.12.009

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HaloTag forms an intramolecular disulfide

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