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Copper concentrations in the cerebellum also increased with age, but in AD mice, while copper levels did not significantly change (MannWhitney U , p = 0.063), significant changes in copper isotope ratios were observed (MannWhitney U , p = 0.016), with a notable enrichment in copper isotope ratios in AD transgenic mice (65Cu = 0.33) (81)

[50] Additionally, vitamin B12 is crucial for neurological functioning and can impact cognitive function, especially in older adults with mild deficiencies

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This alteration results in downregulation of IFN- and IL-2 expression, leading to an increased risk of infections [320]