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It exerts effects through modulation of the mTORC1 pathway, promoting autophagy as a protective mechanism against cellular stress and damage

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115 These changes in neuroglia define the susceptibility of the brain to pathology and hence glial performance defines physiological (with cognitive preservation) versus pathological (cognitive decline) brain ageing

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Importantly, once a stroke has occurred, the risk of recurrence and subsequent cognitive impairment increases significantly (79)

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