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The math does not change based on body weight, only the target dose changes

It is the why NNMT is interesting at all paper

See the results, by brand, in the Kefir section of our Probiotic Supplements Review
doi: 10.1016/0014-5793(88)80509-x

and c) irregular dietary patterns), reduced bioavailability (impairment of the intrinsic factor-mediated absorption pathway, often due to the widespread and prolonged use of proton pump inhibitors), and malabsorption syndromes

Pathobiology 1993