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Semaglutide, a novel GLP-1 receptor agonist, was investigated in a recently completed phase 2 placebo-controlled trial comparing the efficacy and safety of different doses in 320 NASH patients and the results are awaited (NCT02970942)

Studies have also suggested that PPAR is stimulated through a PPAR response element in the first and second introns of the human and rat CPT1A genes, respectively ( Reference Napal, Marrero and Haro 47 , Reference Song, Attia and Connauqhton 48 )

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