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clinical effect sizes vary by indication, dosing, individual factors, and adherence

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Am J Kidney Dis 70(2):199-206 2017 PMC5848095 Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark A, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG, TEDDY Study Group

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Then, -N-trimethyllysine enters mitochondria where it undergoes hydroxylation by the -N-trimethyllysine hydroxylase to produce -hydroxy-N--trimethyllysine, a process that requires vitamin C and iron as cofactors [12]

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