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With cyanocobalamin or methylcobalamin, rare skin reactions (acne/rosacea) and gastrointestinal disturbances may occur

Guan D, Li C, Li Y, Li Y, Wang G, Gao F, et al

Yang SY, Taanman JW, Gegg M, Schapira AHV

These cytokines are involved in the activation and maturation of B cells, enabling plasma cells to secrete autoantibodies, inducing injury through complement activation and antibody-mediated cytotoxicity [36]

Considering multiple inflammatory, oxidative, and apoptotic mechanisms behind hepatotoxicity, it urges the need for finding novel multi-targeting agents

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