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Stimulation of TLR4 generally induces the production of pro-inflammatory cytokines, modulates expression of associated receptors (e.g., TLR2), and facilitates immune cell recruitment, culminating in coordinated effector immune responses in systemic organs such as the spleen

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66 , 67 In addition to degrade extracellular matrix proteins and inflammatory mediators such as cohesin, various membrane proteins and IL-8, etc., NE is capable of inhibiting tissue factors and promoting the formation of vascular fibrin

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But most of these drugs are not approved for human consumption by regulators, because we dont fully understand what theyre doing to our bodies